The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor
Identifieur interne : 001408 ( Main/Exploration ); précédent : 001407; suivant : 001409The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor
Auteurs : S. Goldwurm [Italie] ; A Di Fonzo [Italie] ; E J Simons [Pays-Bas] ; C F Rohé [Pays-Bas] ; M. Zini [Italie] ; M. Canesi [Italie] ; S. Tesei [Italie] ; A. Zecchinelli [Italie] ; A. Antonini [Italie] ; C. Mariani [Italie] ; N. Meucci [Italie] ; G. Sacilotto [Italie] ; F. Sironi [Italie] ; G. Salani [Italie] ; J. Ferreira [Portugal] ; H F Chien [Brésil] ; E. Fabrizio [Italie] ; N. Vanacore [Italie] ; A Dalla Libera [Italie] ; F. Stocchi [Italie] ; C. Diroma [Italie] ; P. Lamberti [Italie] ; C. Sampaio [Portugal] ; G. Meco [Italie] ; E. Barbosa [Brésil] ; A M Bertoli-Avella [Pays-Bas] ; G J Breedveld [Pays-Bas] ; B A Oostra [Pays-Bas] ; G. Pezzoli [Italie] ; V. Bonifati [Pays-Bas]Source :
- Journal of Medical Genetics [ 0022-2593 ] ; 2005-11.
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Abstract
Background: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson’s disease. Objective: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (<50 years) and late onset familial and sporadic Parkinson’s disease. Results: Among 629 probands, 13 (2.1%) were heterozygous carriers of the G2019S mutation. The mutation frequency was higher among familial (5.1%, 9/177) than among sporadic probands (0.9%, 4/452) (p<0.002), and highest among probands with one affected parent (8.7%, 6/69) (p<0.001). There was no difference in the frequency of the G2019S mutation in probands with early v late onset disease. Among 600 probands, one heterozygous R1441C but no R1441G or Y1699C mutations were detected. None of the four mutations was found in Italian controls. Haplotype analysis in families from five countries suggested that the G2019S mutation originated from a single ancient founder. The G2019S mutation was associated with the classical Parkinson’s disease phenotype and a broad range of onset age (34 to 73 years). Conclusions: G2019S is the most common genetic determinant of Parkinson’s disease identified so far. It is especially frequent among cases with familial Parkinson’s disease of both early and late onset, but less common among sporadic cases. These findings have important implications for diagnosis and genetic counselling in Parkinson’s disease.
Url:
DOI: 10.1136/jmg.2005.035568
Affiliations:
- Brésil, Italie, Pays-Bas, Portugal
- Hollande-Méridionale, Latium, Lombardie, État de São Paulo
- Milan, Rome, Rotterdam, São Paulo
- Université de São Paulo
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor</title><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S" last="Goldwurm">S. Goldwurm</name></author><author><name sortKey="Fonzo, A Di" sort="Fonzo, A Di" uniqKey="Fonzo A" first="A Di" last="Fonzo">A Di Fonzo</name></author><author><name sortKey="Simons, E J" sort="Simons, E J" uniqKey="Simons E" first="E J" last="Simons">E J Simons</name></author><author><name sortKey="Rohe, C F" sort="Rohe, C F" uniqKey="Rohe C" first="C F" last="Rohé">C F Rohé</name></author><author><name sortKey="Zini, M" sort="Zini, M" uniqKey="Zini M" first="M" last="Zini">M. Zini</name></author><author><name sortKey="Canesi, M" sort="Canesi, M" uniqKey="Canesi M" first="M" last="Canesi">M. Canesi</name></author><author><name sortKey="Tesei, S" sort="Tesei, S" uniqKey="Tesei S" first="S" last="Tesei">S. Tesei</name></author><author><name sortKey="Zecchinelli, A" sort="Zecchinelli, A" uniqKey="Zecchinelli A" first="A" last="Zecchinelli">A. Zecchinelli</name></author><author><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name></author><author><name sortKey="Mariani, C" sort="Mariani, C" uniqKey="Mariani C" first="C" last="Mariani">C. Mariani</name></author><author><name sortKey="Meucci, N" sort="Meucci, N" uniqKey="Meucci N" first="N" last="Meucci">N. Meucci</name></author><author><name sortKey="Sacilotto, G" sort="Sacilotto, G" uniqKey="Sacilotto G" first="G" last="Sacilotto">G. Sacilotto</name></author><author><name sortKey="Sironi, F" sort="Sironi, F" uniqKey="Sironi F" first="F" last="Sironi">F. Sironi</name></author><author><name sortKey="Salani, G" sort="Salani, G" uniqKey="Salani G" first="G" last="Salani">G. Salani</name></author><author><name sortKey="Ferreira, J" sort="Ferreira, J" uniqKey="Ferreira J" first="J" last="Ferreira">J. Ferreira</name></author><author><name sortKey="Chien, H F" sort="Chien, H F" uniqKey="Chien H" first="H F" last="Chien">H F Chien</name></author><author><name sortKey="Fabrizio, E" sort="Fabrizio, E" uniqKey="Fabrizio E" first="E" last="Fabrizio">E. Fabrizio</name></author><author><name sortKey="Vanacore, N" sort="Vanacore, N" uniqKey="Vanacore N" first="N" last="Vanacore">N. Vanacore</name></author><author><name sortKey="Libera, A Dalla" sort="Libera, A Dalla" uniqKey="Libera A" first="A Dalla" last="Libera">A Dalla Libera</name></author><author><name sortKey="Stocchi, F" sort="Stocchi, F" uniqKey="Stocchi F" first="F" last="Stocchi">F. Stocchi</name></author><author><name sortKey="Diroma, C" sort="Diroma, C" uniqKey="Diroma C" first="C" last="Diroma">C. Diroma</name></author><author><name sortKey="Lamberti, P" sort="Lamberti, P" uniqKey="Lamberti P" first="P" last="Lamberti">P. Lamberti</name></author><author><name sortKey="Sampaio, C" sort="Sampaio, C" uniqKey="Sampaio C" first="C" last="Sampaio">C. Sampaio</name></author><author><name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G" last="Meco">G. Meco</name></author><author><name sortKey="Barbosa, E" sort="Barbosa, E" uniqKey="Barbosa E" first="E" last="Barbosa">E. Barbosa</name></author><author><name sortKey="Bertoli Avella, A M" sort="Bertoli Avella, A M" uniqKey="Bertoli Avella A" first="A M" last="Bertoli-Avella">A M Bertoli-Avella</name></author><author><name sortKey="Breedveld, G J" sort="Breedveld, G J" uniqKey="Breedveld G" first="G J" last="Breedveld">G J Breedveld</name></author><author><name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G" last="Pezzoli">G. Pezzoli</name></author><author><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V" last="Bonifati">V. Bonifati</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F93943A446D88EA8C4635BDE09A1CFC04C5ACD54</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1136/jmg.2005.035568</idno><idno type="url">https://api.istex.fr/document/F93943A446D88EA8C4635BDE09A1CFC04C5ACD54/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D50</idno><idno type="wicri:Area/Main/Curation">000B91</idno><idno type="wicri:Area/Main/Exploration">001408</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor</title><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S" last="Goldwurm">S. Goldwurm</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fonzo, A Di" sort="Fonzo, A Di" uniqKey="Fonzo A" first="A Di" last="Fonzo">A Di Fonzo</name><affiliation wicri:level="3"><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Centro Dino Ferrari, Department of Neurological Sciences, University of Milan, and Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”</wicri:orgArea></affiliation></author><author><name sortKey="Simons, E J" sort="Simons, E J" uniqKey="Simons E" first="E J" last="Simons">E J Simons</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rohe, C F" sort="Rohe, C F" uniqKey="Rohe C" first="C F" last="Rohé">C F Rohé</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zini, M" sort="Zini, M" uniqKey="Zini M" first="M" last="Zini">M. Zini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Canesi, M" sort="Canesi, M" uniqKey="Canesi M" first="M" last="Canesi">M. Canesi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tesei, S" sort="Tesei, S" uniqKey="Tesei S" first="S" last="Tesei">S. Tesei</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Zecchinelli, A" sort="Zecchinelli, A" uniqKey="Zecchinelli A" first="A" last="Zecchinelli">A. Zecchinelli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Mariani, C" sort="Mariani, C" uniqKey="Mariani C" first="C" last="Mariani">C. Mariani</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Meucci, N" sort="Meucci, N" uniqKey="Meucci N" first="N" last="Meucci">N. Meucci</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sacilotto, G" sort="Sacilotto, G" uniqKey="Sacilotto G" first="G" last="Sacilotto">G. Sacilotto</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, F" sort="Sironi, F" uniqKey="Sironi F" first="F" last="Sironi">F. Sironi</name><affiliation wicri:level="3"><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Molecular Genetics Laboratory, IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena</wicri:orgArea></affiliation></author><author><name sortKey="Salani, G" sort="Salani, G" uniqKey="Salani G" first="G" last="Salani">G. Salani</name><affiliation wicri:level="3"><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Neuroimmunology Unit, San Raffaele Scientific Institute</wicri:orgArea></affiliation></author><author><name sortKey="Ferreira, J" sort="Ferreira, J" uniqKey="Ferreira J" first="J" last="Ferreira">J. Ferreira</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Chien, H F" sort="Chien, H F" uniqKey="Chien H" first="H F" last="Chien">H F Chien</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Fabrizio, E" sort="Fabrizio, E" uniqKey="Fabrizio E" first="E" last="Fabrizio">E. Fabrizio</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Vanacore, N" sort="Vanacore, N" uniqKey="Vanacore N" first="N" last="Vanacore">N. Vanacore</name><affiliation wicri:level="3"><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>National Centre of Epidemiology, National Institute for Health</wicri:orgArea></affiliation></author><author><name sortKey="Libera, A Dalla" sort="Libera, A Dalla" uniqKey="Libera A" first="A Dalla" last="Libera">A Dalla Libera</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurology Division, “Boldrini” Hospital, Thiene</wicri:regionArea><wicri:noRegion>Thiene</wicri:noRegion></affiliation></author><author><name sortKey="Stocchi, F" sort="Stocchi, F" uniqKey="Stocchi F" first="F" last="Stocchi">F. Stocchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCSS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Diroma, C" sort="Diroma, C" uniqKey="Diroma C" first="C" last="Diroma">C. Diroma</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Lamberti, P" sort="Lamberti, P" uniqKey="Lamberti P" first="P" last="Lamberti">P. Lamberti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Sampaio, C" sort="Sampaio, C" uniqKey="Sampaio C" first="C" last="Sampaio">C. Sampaio</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G" last="Meco">G. Meco</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Barbosa, E" sort="Barbosa, E" uniqKey="Barbosa E" first="E" last="Barbosa">E. Barbosa</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bertoli Avella, A M" sort="Bertoli Avella, A M" uniqKey="Bertoli Avella A" first="A M" last="Bertoli-Avella">A M Bertoli-Avella</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Breedveld, G J" sort="Breedveld, G J" uniqKey="Breedveld G" first="G J" last="Breedveld">G J Breedveld</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G" last="Pezzoli">G. Pezzoli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V" last="Bonifati">V. Bonifati</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Medical Genetics</title><title level="j" type="abbrev">J Med Genet</title><idno type="ISSN">0022-2593</idno><idno type="eISSN">1468-6244</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2005-11">2005-11</date><biblScope unit="volume">42</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="e65">e65</biblScope></imprint><idno type="ISSN">0022-2593</idno></series><idno type="istex">F93943A446D88EA8C4635BDE09A1CFC04C5ACD54</idno><idno type="DOI">10.1136/jmg.2005.035568</idno><idno type="href">jmedgenet-42-e65.pdf</idno><idno type="PMID">16272257</idno><idno type="local">042e065</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2593</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>G2019S</term><term>LD, linkage disequilibrium</term><term>LRRK2</term><term>Parkinson’s disease</term><term>SNP, single nucleotide polymorphism</term><term>founder</term><term>mutation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson’s disease. Objective: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (<50 years) and late onset familial and sporadic Parkinson’s disease. Results: Among 629 probands, 13 (2.1%) were heterozygous carriers of the G2019S mutation. The mutation frequency was higher among familial (5.1%, 9/177) than among sporadic probands (0.9%, 4/452) (p<0.002), and highest among probands with one affected parent (8.7%, 6/69) (p<0.001). There was no difference in the frequency of the G2019S mutation in probands with early v late onset disease. Among 600 probands, one heterozygous R1441C but no R1441G or Y1699C mutations were detected. None of the four mutations was found in Italian controls. Haplotype analysis in families from five countries suggested that the G2019S mutation originated from a single ancient founder. The G2019S mutation was associated with the classical Parkinson’s disease phenotype and a broad range of onset age (34 to 73 years). Conclusions: G2019S is the most common genetic determinant of Parkinson’s disease identified so far. It is especially frequent among cases with familial Parkinson’s disease of both early and late onset, but less common among sporadic cases. These findings have important implications for diagnosis and genetic counselling in Parkinson’s disease.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li></country><region><li>Hollande-Méridionale</li><li>Latium</li><li>Lombardie</li><li>État de São Paulo</li></region><settlement><li>Milan</li><li>Rome</li><li>Rotterdam</li><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S" last="Goldwurm">S. Goldwurm</name></region><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name><name sortKey="Canesi, M" sort="Canesi, M" uniqKey="Canesi M" first="M" last="Canesi">M. Canesi</name><name sortKey="Diroma, C" sort="Diroma, C" uniqKey="Diroma C" first="C" last="Diroma">C. Diroma</name><name sortKey="Fabrizio, E" sort="Fabrizio, E" uniqKey="Fabrizio E" first="E" last="Fabrizio">E. Fabrizio</name><name sortKey="Fonzo, A Di" sort="Fonzo, A Di" uniqKey="Fonzo A" first="A Di" last="Fonzo">A Di Fonzo</name><name sortKey="Lamberti, P" sort="Lamberti, P" uniqKey="Lamberti P" first="P" last="Lamberti">P. Lamberti</name><name sortKey="Libera, A Dalla" sort="Libera, A Dalla" uniqKey="Libera A" first="A Dalla" last="Libera">A Dalla Libera</name><name sortKey="Mariani, C" sort="Mariani, C" uniqKey="Mariani C" first="C" last="Mariani">C. Mariani</name><name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G" last="Meco">G. Meco</name><name sortKey="Meucci, N" sort="Meucci, N" uniqKey="Meucci N" first="N" last="Meucci">N. Meucci</name><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G" last="Pezzoli">G. Pezzoli</name><name sortKey="Sacilotto, G" sort="Sacilotto, G" uniqKey="Sacilotto G" first="G" last="Sacilotto">G. Sacilotto</name><name sortKey="Salani, G" sort="Salani, G" uniqKey="Salani G" first="G" last="Salani">G. Salani</name><name sortKey="Sironi, F" sort="Sironi, F" uniqKey="Sironi F" first="F" last="Sironi">F. Sironi</name><name sortKey="Stocchi, F" sort="Stocchi, F" uniqKey="Stocchi F" first="F" last="Stocchi">F. Stocchi</name><name sortKey="Tesei, S" sort="Tesei, S" uniqKey="Tesei S" first="S" last="Tesei">S. Tesei</name><name sortKey="Vanacore, N" sort="Vanacore, N" uniqKey="Vanacore N" first="N" last="Vanacore">N. Vanacore</name><name sortKey="Zecchinelli, A" sort="Zecchinelli, A" uniqKey="Zecchinelli A" first="A" last="Zecchinelli">A. Zecchinelli</name><name sortKey="Zini, M" sort="Zini, M" uniqKey="Zini M" first="M" last="Zini">M. Zini</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Simons, E J" sort="Simons, E J" uniqKey="Simons E" first="E J" last="Simons">E J Simons</name></region><name sortKey="Bertoli Avella, A M" sort="Bertoli Avella, A M" uniqKey="Bertoli Avella A" first="A M" last="Bertoli-Avella">A M Bertoli-Avella</name><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V" last="Bonifati">V. Bonifati</name><name sortKey="Breedveld, G J" sort="Breedveld, G J" uniqKey="Breedveld G" first="G J" last="Breedveld">G J Breedveld</name><name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name><name sortKey="Rohe, C F" sort="Rohe, C F" uniqKey="Rohe C" first="C F" last="Rohé">C F Rohé</name></country><country name="Portugal"><noRegion><name sortKey="Ferreira, J" sort="Ferreira, J" uniqKey="Ferreira J" first="J" last="Ferreira">J. Ferreira</name></noRegion><name sortKey="Sampaio, C" sort="Sampaio, C" uniqKey="Sampaio C" first="C" last="Sampaio">C. Sampaio</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Chien, H F" sort="Chien, H F" uniqKey="Chien H" first="H F" last="Chien">H F Chien</name></region><name sortKey="Barbosa, E" sort="Barbosa, E" uniqKey="Barbosa E" first="E" last="Barbosa">E. Barbosa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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